Check out the companies making the biggest moves midday: AppFolio — The cloud-based business software provider climbed 7% after an upgrade to overweight from equal weight at KeyBanc, with a 12-month price target of $285, according to FactSet’s StreetAccount service. AST SpaceMobile — Shares in the space-based broadband cellular network dropped 6% after more than doubling in the past month. Barclays double downgraded its investment rating to underweight from overweight while leaving its price target at $60, StreetAccount said. Revolution Medicines — The late-stage clinical oncology company jumped 10% after saying the Food and Drug Administration granted a voucher for daraxonrasib (RMC-6236), a multi-selective inhibitor, under the National Priority Voucher pilot program. Daraxonrasib is aimed at treating patients with metastatic pancreatic ductal adenocarcinoma and metastatic non-small cell lung cancer patients. Core Scientific — The quantum computing company fell more than 5% after CoreWeave responded to a letter from investor Two Seas Capital that opposed the company’s acquisition of Core Scientific. CoreWeave called its offer “best and final.” State Street — The asset manager fell more than 3% after reporting mixed results for the third quarter . Earnings and revenue beat expectations. Net interest income of $715 million came in below a FactSet estimate of $740.2 million. Regional banks — The group ticked higher after driving down the broader market on Thursday. Zions rallied more than 4% on the back of a Baird upgrade , while Western Alliance bounced 2% higher. The SPDR S & P Regional Banking ETF (KRE) advanced 1%. Jefferies — The investment bank’s shares jumped 4.2% following Thursday’s plunge of more than 10%. Oppenheimer upgraded the stock to outperform on Friday, with the firm saying Jefferies’ exposure to First Brands is “very limited.” CSX — The Jacksonville, Florida-based railroad added 3% following better-than-expected earnings for the third quarter. CSX reported adjusted earnings of 44 cents per share on $3.59 billion in revenue, while analysts polled by LSEG penciled in 42 cents a share and $3.58 billion. Interactive Brokers Group — Shares fell 3% after an expectation-beating earnings report for the third quarter. Interactive Brokers recorded earnings of 57 cents per share, excluding items, and $1.61 billion in revenue. That topped an LSEG of 54 cents in earnings per share and $1.52 billion in revenue. Oracle — The software stock shed 7%, giving back a chunk of its rally in Thursday’s session. Oracle on Thursday confirmed a cloud computing deal with Meta. Bank OZK — The regional bank slipped 3% as third-quarter earnings missed expectations, adding to losses seen during Thursday’s regional bank sell-off. Bank OZK earned $1.59 per share, missing the consensus forecast for $1.66 a share from analysts surveyed by FactSet. Novo Nordisk , Eli Lilly — The pharmaceutical stocks lost between 3% and 4% after President Donald Trump suggested obesity drug costs could be “much lower.” However, Dr. Mehmet Oz, administrator of the Centers for Medicare & Medicaid Services, noted that the price of the popular GLP-1 medications had not yet been negotiated by the White House. Fifth Third Bancorp — Shares of the bank, which announced its acquisition of Comerica last week, gained 1% on the back of a better-than-expected earnings report for the third quarter. Fifth Third earned 91 cents per share and $2.31 billion in revenue, while analysts surveyed by LSEG forecasted 87 cents and $2.28 billion. Comerica shares rose 0.8% after also posting earnings. Micron Technology — Shares traded 2% lower after Reuters reported , citing sources, that Micron would exit the server chips business in China. Reuters reported that Micron’s business in the Asian country had failed to recover following a 2023 ban on its products in critical infrastructure. American Express — The financial stock added 6% after beating expectations for the third quarter and raising its full-year guidance. American Express said it earned $4.14 per share on $18.43 billion in the quarter, while analysts polled by FactSet anticipated $4 a share and $18.05 billion. Truist Financial — The bank’s stock rose 3.5% on a stronger-than-anticipated third-quarter earnings report. Truist earned $1.07 per share, excluding items, and $5.24 billion in revenue, while analysts were expecting $1 and $5.20 billion. Intuitive Machines — The space technology stock rallied 3% on the heels of Deutsche Bank’s upgrade to buy from hold. Deutsche said the stock’s risk-to-reward ratio looks attractive and that the business has commercial catalysts on the horizon. — CNBC’s Alex Harring, Fred Imbert and Pia Singh contributed reporting (Learn the best 2026 strategies from inside the NYSE with Josh Brown and others at CNBC PRO Live. Tickets and info here .)
Stocks making big moves midday: ORCL ASTS, RVMD